This article reviews terpenoid fermentation and separation, providing references for large-scale, high-purity terpenoid production to boost the field. Future research should focus on developing efficient, eco-friendly and cost-effective separation techniques or optimizing existing ones to handle terpenoid challenges. Interdisciplinary efforts, such as those in materials science and artificial intelligence, will cut impurities, boost purity, meet market demands and unlock value in pharma, food and cosmetics.

This work was supported by National Natural Science Foundation of China, China, Natural Science Foundation of Shandong Province, China, Qingdao New Energy Shandong Laboratory Open Project.

Link:  https://doi.org/10.1016/j.tifs.2025.105098